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Formerly the Hypertension Core Laboratory
The Biomarker Analytical Core (BAC) at Wake Forest School of Medicine is a CLIA-certified laboratory that performs clinical and research assays. It serves as a reference laboratory for Wake Forest Baptist Medical Center, Winston-Salem, NC, as well as a central laboratory for Hypertension and Vascular Research. The laboratory has participated in NIH, FDA, and pharmaceutical company-sponsored studies and has experience with multi-center projects. K. Bridget Brosnihan, Ph.D. is certified as a high complexity assay laboratory director.
The BAC provides analytical support for individual projects and for program project grants within the institution, as well as for national and international investigators.
The majority of the analytes are measured by radioimmunoassay (RIA), enzyme immunoassay (EIA), and enzymatic assays. By having all the samples analyzed by staff with long-term experience, in a single laboratory equipped with appropriate instrumentation, data can be obtained in a more uniform manner, with the strictest possible quality control and minimal reagent expense.
The BAC is nationally and internationally recognized as an expert in measurement of components of the renin-angiotensin system, and provides biomarkers of cardiovascular, inflammatory, and aging-related and metabolic diseases.
K. Bridget Brosnihan, PhD, HCLD
Director
Phone: (336) 716-2795
E-mail: Kathleen.Brosnihansimmons@advocatehealth.org
TanYa Gwathmey-Williams, PhD
Co-Director
Phone: (336) 716-9524
E-mail: Tanya.Gwathmeywilliams@advocatehealth.org
Pam Dean
Lab Manager/Tech
Phone: (336)-716-3553
E-mail: Pam.Dean@advocatehealth.org
| Hours | Location |
|
Monday - Friday 8:30 AM - 5:00 PM |
Biomarker Analytical Core |
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Pam Dean |
Lab Manager
|
(336) 716-3553
|
Pam.Dean@advocatehealth.org
|
Biotech Place
|
| TanYa Gwathmey |
Co-Director
|
(336) 716-9524
|
Tanya.Gwathmeywilliams@advocatehealth.org
|
Biotech Place
|
| K. Bridget Brosnihan |
Professor, High Complexity Laboratory Director
|
(336) 716-2795
|
Kathleen.Brosnihansimmons@advocatehealth.org
|
Biotech Place
|
| Katie Busalacchi |
Lab Tech
|
(336)716-1856
|
Katie.Busalacchi@advocatehealth.org
|
Biotech Place
|
| Service list |
| ► Assays (165) | |||
| Name | Description | Price | |
|---|---|---|---|
| Ferritin Human (ng/ml) |
Internal
$45.00
each
External $70.00 each |
||
| ACE (Protein) Human (ng/ml) | Inquire | ||
| ACE (Protein) RAT (ng/ml) | Inquire | ||
| ACE(Protein) RAT Tiss (mU/mg protein) | Inquire | ||
| ACE2 (Protein) Human (ng/ml) | Inquire | ||
| ACE2 (Protein) Rat (ng/ml) | Inquire | ||
| ACE2(Protein) RAT Tiss (mU/mg protein) | Inquire | ||
| Acetoacetate (mM) |
Internal
$54.00
each
External $84.00 each |
||
| ACTH (ELISA) (pg/ml) | Inquire | ||
| Adiponectin (ng/ml) | Inquire | ||
| Adiponectin HMW (ng/ml) | Inquire | ||
| ADMA (Asymmetric Dimethyl (umol/l) | Inquire | ||
| Albumin (Mouse) (ng/ml) | Inquire | ||
| Albumin(Human-Plasma, Serum) (ng/ml) | Inquire | ||
| Albumin(Human-Urine, Amniotic Fluid) (ng/ml) | Inquire | ||
| Aldosterone (ng/dl) | Inquire | ||
| Aldosterone (Urine / Amniotic Fluid) (ng/dl) | Inquire | ||
| alpha-Amylase (Salivary) (U/ml) | Inquire | ||
| Amylin (Human) (pM) | Inquire | ||
| AngHuman1-12(EIA) (pg/ml) | Inquire | ||
| AngHuman1-12(EIA)Direct (pg/tube) | Inquire | ||
| AngHuman1-12(EIA)Tissue (pg/mg protein) | Inquire | ||
| AngHumExt 1-12(EIA)/Single (pg/ml) | Inquire | ||
| AngHumExt 1-12(EIA)Dup (pg/ml) | Inquire | ||
| Angio Rat 1-12 (pg/ml) | Inquire | ||
| Angio Rat 1-12(Direct) (pg/tube) | Inquire | ||
| Angio Rat 1-12/Single (pg/ml) | Inquire | ||
| Angio Rat 1-12/Tissue (pg/mg protein) | Inquire | ||
| Angiotensin 1-7 (Direct) (pg/tube) | Inquire | ||
| Angiotensin 1-7 (pg/ml) | Inquire | ||
| Angiotensin 1-7/Single (pg/ml) | Inquire | ||
| Angiotensin 1-7 Tissue (pg/mg protein) | Inquire | ||
| Angiotensin I (pg/ml) | Inquire | ||
| Angiotensin I /Direct (pg/tube) | Inquire | ||
| Angiotensin I/Single (pg/ml) | Inquire | ||
| Angiotensin I/Tissue (pg/mg protein) | Inquire | ||
| Angiotensin II (pg/ml) | Inquire | ||
| Angiotensin II / Direct (pg/tube) | Inquire | ||
| Angiotensin II/Single (pg/ml) | Inquire | ||
| Angiotensin II/Tissue (pg/mg protein) | Inquire | ||
| Angiotensinogen(Aogen) HUMAN (ng/ml) | Inquire | ||
| ANP (RIA) (pg/ml) | Inquire | ||
| Apelin (EIA w/o Extraction) (ng/ml) | Inquire | ||
| Apelin-36 (Plasma w/Extraction) (pg/ml) | Inquire | ||
| Apelin-36 (Tissue /homo-extraction) (pg/mg protein) | Inquire | ||
| Apelin36(TissExtract) only | Inquire | ||
| beta-Hydroxybutyrate (mM) |
Internal
$34.00
each
Industry $34.00 each External $52.70 each |
||
| Blood In Urine | Inquire | ||
| BNP (pg/ml) | Inquire | ||
| Bradykinin (pg/ml) | Inquire | ||
| BUN (mg/dl) |
Internal
$28.00
each
Industry $28.00 each External $43.40 each |
||
| C-GMP (ELISA) (pmol/ml) | Inquire | ||
| C-Peptide (ng/ml) | Inquire | ||
| C-Peptide (Porcine) (ng/ml) | Inquire | ||
| C-Reactive Protein (mg/dl) | Inquire | ||
| Carbon Dioxide (Total) (mmol/L) | Inquire | ||
| CD-40 (pg/ml) | Inquire | ||
| CGRP(Human)Tissue (ng/ml) | Inquire | ||
| Clonidine (ng/ml) | Inquire | ||
| CNP (pg/ml) | Inquire | ||
| COMP (ng/ml) | Inquire | ||
| Copeptin (pg/ml) | Inquire | ||
| Corticosterone (ng/ml) | Inquire | ||
| Cortisol EIA (Salivary) (ug/dl) | Inquire | ||
| Cortisol Human (Blood) (ng/ml) | Inquire | ||
| Creatinine (Serum) (mg/dl) | Inquire | ||
| Creatinine (Urine, Amniotic Fluid) (mg/dl) | Inquire | ||
| CRP ( Mice) (ng/ml) | Inquire | ||
| Cystatin C (Human) (ng/ml) | Inquire | ||
| Desmosine (pg/ml) | Inquire | ||
| DHEA (ng/ml) | Inquire | ||
| DHEA-S (ng/ml) | Inquire | ||
| DNA Damage/8-OHdG (ng/ml) | Inquire | ||
| Dopamine (Plasma) (pg/ml) | Inquire | ||
| Dopamine (Urine) (ng/ml) | Inquire | ||
| E-Selectin (ng/ml) |
Internal
$41.00
each
Industry $41.00 each External $41.00 each |
||
| Elabela (Tissue) Assay ONLY (ng/mg/protein) | Inquire | ||
| Elabela Human(EIA)Plasma (ng/ml) | Inquire | ||
| Elabela Human(EIA)Tisssue (ng/mg/protein) | Inquire | ||
| Endoglin (ng/ml) | Inquire | ||
| Endothelin-1 Human (pg/ml) | Inquire | ||
| Epinephrine (Plasma) (pg/ml) | Inquire | ||
| Epinephrine (Tissue) (pg/mg protein) |
Internal
$80.00
each
Industry $80.00 each External $80.00 each |
||
| Epinephrine(Urine) (ng/ml) | Inquire | ||
| Estradiol (Rat) pg/ml | Inquire | ||
| Estrone (pg/ml) | Inquire | ||
| FGF-23 Total Human Serum (pg/ml) | Inquire | ||
| Fractalkine (pg/ml) | Inquire | ||
| Galectin 3 (ng/ml) | Inquire | ||
| Ghrelin (Human) (pg/ml) |
Internal
$45.00
each
Industry $45.00 each External $45.00 each |
||
| GLP-1(7-36a)Human (pg/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| Glucose(Strips) Whole Blood (mg/dl) | Inquire | ||
| Glycogen Phosphorylase (pg/ml) | Inquire | ||
| Growth Hormone (ng/ml) | Inquire | ||
| HGF (pg/ml) | Inquire | ||
| ICAM (ng/ml) | Inquire | ||
| IGF-1 Human (ng/ml) | Inquire | ||
| IL-10 (pg/ml) | Inquire | ||
| IL-12 (Pig) (ng/ml) | Inquire | ||
| IL-12p70 (pg/ml) | Inquire | ||
| IL-1alpha (pg/ml) | Inquire | ||
| IL-1beta (pg/ml) | Inquire | ||
| IL-1RA (pg/ml) | Inquire | ||
| IL-2 (pg/ml) | Inquire | ||
| IL-4 (pg/ml) | Inquire | ||
| IL-5 (pg/ml) | Inquire | ||
| IL-6 (pg/ml) | Inquire | ||
| IL-8 (pg/ml) | Inquire | ||
| IL-sRII (pg/ml) | Inquire | ||
| Insulin (Human) (uIU/ml) | Inquire | ||
| Insulin (Rat) (ng/ml) | Inquire | ||
| Isoprostane-8 *Urine* (pg/ml) | Inquire | ||
| Isoprostane-8 (Plasma)pg/ml | Inquire | ||
| alpha-Klotho Human(pg/ml) |
Internal
$55.00
each
External $85.25 each |
||
| Leptin (Human) (ng/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| Leptin (Multispecies) (ng/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| LTB4 (pg/ml) | Inquire | ||
| M-CSF (pg/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| MCP-1 (ng/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| MDA (Malondialdehyde)ng/ml |
Internal
$48.00
each
Industry $48.00 each External $48.00 each |
||
| Metanephrine -Plasma (pg/ml) |
Internal
$55.00
each
External $55.00 each |
||
| NEP (Protein) Human (pg/ml) |
Internal
$50.00
each
Industry $50.00 each External $68.00 each |
||
| NEP (Protein) Rat-MiceTissue (pg/mg protein) |
Internal
$80.00
each
Industry $80.00 each External $80.00 each |
||
| NEP(Protein) Rat-Mice (pg/ml) | Inquire | ||
| NorEpinephrine (Plasma) (pg/ml) |
Internal
$60.00
each
External $60.00 each |
||
| NorEpinephrine (Tissue) (ng/mg protein) |
Internal
$100.00
each
External $1,550.00 each |
||
| NorEpinephrine (Urine) (ng/ml) |
Internal
$60.00
each
External $60.00 each |
||
| NorMetanephrine (Urine) (ng/ml) |
Internal
$55.00
each
External $74.80 each |
||
| Osteocalcin (ng/ml) | Inquire | ||
| Oxytocin (pg/ml) | Inquire | ||
| P-Selectin (ng/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| PAI-1 (ng/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| PLGF (pg/ml) | Inquire | ||
| s(Pro)Renin Receptor Human pg/ml | Inquire | ||
| Progesterone (Human) ng/ml | Inquire | ||
| Prostaglandin E2- Urine (pg/ml) | Inquire | ||
| Prostaglandin E2 (Plasma) (pg/ml) | Inquire | ||
| Prostaglandin F1a - Urine (pg/ml) | Inquire | ||
| Prostaglandin F1a(Plasma) (pg/ml) |
Internal
$55.00
each
Industry $55.00 each External $74.80 each |
||
| Prostaglandin F2a - Urine (pg/ml) | Inquire | ||
| Prostaglandin F2a(Plasma) (pg/ml) | Inquire | ||
| Protein (mg/ml) | Inquire | ||
| Renin (Ang I) *Direct* (ng/100ul) |
Internal
$37.00
each
Industry $37.00 each External $50.32 each |
||
| Renin Activity (ng/ml/hr) | Inquire | ||
| Renin Concentration(PRC) (ng/ml/hr) | Inquire | ||
| Resistin (ng/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| SHBG (nmol/l) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| SOD (Superoxide Dismulase) (U/ml) |
Internal
$48.00
each
Industry $48.00 each External $48.00 each |
||
| Substance (Ppg/ml) |
Internal
$55.00
each
Industry $55.00 each External $74.80 each |
||
| sVEGF R1/sFlt-1 (pg/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| TGF-beta1 (pg/ml) |
Internal
$43.00
each
Industry $43.00 each External $58.48 each |
||
| Thrombomodulin (pg/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| Thromboxane B2 (Plasma) (pg/ml) |
Internal
$55.00
each
External $85.00 each |
||
| TIMP-1 (pg/ml) |
Internal
$55.00
each
Industry $55.00 each External $74.80 each |
||
| TIMP-2 (pg/ml) |
Internal
$55.00
each
Industry $55.00 each External $74.80 each |
||
| TIMP-4 (pg/ml) |
Internal
$55.00
each
Industry $55.00 each External $74.80 each |
||
| TNF-alpha (Human) (pg/ml) |
Internal
$48.00
each
External $74.00 each |
||
| TNF-beta (pg/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| Troponin I Human(pg/ml) |
Internal
$48.00
each
Industry $48.00 each External $48.00 each |
||
| Vasopressin (Plasma) (pg/ml) |
Internal
$55.00
each
Industry $55.00 each External $55.00 each |
||
| Vasopressin (Urine) (pg/ml) | Inquire | ||
| VCAM (ng/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| VEGF (pg/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| Vit D 25-Hydroxy (ng/ml) |
Internal
$41.00
each
Industry $41.00 each External $55.76 each |
||
| Vitamin B6 Human(ng/ml) | Inquire | ||
